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Roger Wartell
Georgia Institute of Technology

Biography

Roger Wartell received his B.S. degree in Physics from Stevens Institute of Technology in 1966. In 1971 he received his Ph.D in Physics from the University of Rochester where he worked in the group of Elliot Montroll on the DNA helix-coil transition. From 1971-1973 he was a NIH postdoctoral fellow in the laboratory of Robert Wells at the University of Wisconsin-Madison. He was a Visiting Professor at the University of Wisconsin-Madison in 1978-79, and Visiting Scholar at National Institutes of Health-Bethesda from 1987-88. He joined the faculty at Georgia Tech in 1974. Roger received a NIH Career Development Award in 1979 and served as Associate Chair in School of Physics from 1987-88, and Chair of the School of Biology from 1990-2004. He is a member of the NASA Astrobiology Institute at Georgia Tech. His current research is focused on protein-RNA interactions relating to sRNA regulation in bacteria, and the assembly and reactions of small RNAs in ice.

Selected Recent Publications

The influence of Escherichia coli Hfq mutations on RNA binding and sRNA•mRNA duplex formation in rpoS riboregulation. T. B. Updegrove and R. M. Wartell Biochim. Biophys. Acta 1809, 532–540, 2011
The stoichiometry of the Escherichia coli Hfq protein bound to RNA T. B. Updegrove, J.J. Correia, Y. Chen, C. Terry, R M. Wartell RNA 17, 489-499, 2011.
E. coli DNA associated with Hfq interacts with Hfq’s distal surface and C-terminal domain. T. Updegrove, J.J. Correia, R. Galletto, W. Bujalowski, R. M. Wartell Biochim Biophys Acta. 1799, 588-96, 2010.
RNA tetraloop folding reveals tension between backbone restraints and molecular interactions. S. Mohan, C. Hsiao, J.C. Bowman, R.M. Wartell, L.D. Williams, J Am Chem Soc. 132, 12679-89, 2010.
Conversion of Stable RNA Hairpin to a Metastable Dimer in Frozen Solution X. Sun, J.M. Li, and R.M. Wartell RNA 13, 2277-2286, 2008

Current Projects

NAI Project Collaborators

Publications

  • Galyuk, E. N., Wartell, R. M., Dosin, Y. M., & Lando, D. Y. (2009). DNA Denaturation Under Freezing in Alkaline Medium. Journal of Biomolecular Structure and Dynamics, 26(4), 517–523. doi:10.1080/07391102.2009.10507267

    See Project

  • Mohan, S., Hsiao, C., VanDeusen, H., Gallagher, R., Krohn, E., Kalahar, B., … Williams, L. D. (2009). Mechanism of RNA Double Helix-Propagation at Atomic Resolution †. J. Phys. Chem. B, 113(9), 2614–2623. doi:10.1021/jp8039884

    See Project

  • Updegrove, T. B., & Wartell, R. M. (2011). The influence of Escherichia coli Hfq mutations on RNA binding and sRNA•mRNA duplex formation in rpoS riboregulation. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, 1809(10), 532–540. doi:10.1016/j.bbagrm.2011.08.006

    See Project

  • Updegrove, T. B., Correia, J. J., Galletto, R., Bujalowski, W., & Wartell, R. M. (2010). E. coli DNA associated with isolated Hfq interacts with Hfq’s distal surface and C-terminal domain. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, 1799(8), 588–596. doi:10.1016/j.bbagrm.2010.06.007

    See Project
  • Jain, K., Updegrove, T.B. & Wartell, R.M.  (2011).  Thermodynamics of sRNA-mRNA interactions and the role of Hfq.  In: Sheardy, R. (Eds.).  Frontiers in Nucleic Acids (ACS Symposium Series). See Project
  • Updegrove, T., Wilf, N., Sun, X. & Wartell, R.M.  (2008).  The effect of Hfq on RprA-rpoS mRNA pairing: Hfq-RNA interactions and the influence of the 5’ RpoS mRNA leader region.  Biochemistry, 47: 11184-11195. See Project

Past NAI Teams