NAI
Eric Shepard
Montana State University
Current Projects
- Molecular Evolution: A Top Down Approach to Examine the Origin of Key Biochemical Processes — 2012 NAI
- Radical SAM Chemistry and Biological Ligand Accelerated Catalysis — 2012 NAI
- BioInspired Mimetic Cluster Synthesis: Bridging the Structure and Reactivity of Biotic and Abiotic Iron-Sulfur Motifs — 2012 NAI
- Molecular Evolution: A Top Down Approach to Examine the Origin of Key Biochemical Processes — 2011 NAI
- Radical SAM Chemistry and Biological Ligand Accelerated Catalysis — 2011 NAI
- Paradigms for Complex Iron-Sulfur Cluster Assembly and the Origin and Evolution of Iron-Sulfur Enzymes — 2011 NAI
- BioInspired Mimetic Cluster Synthesis: Bridging the Structure and Reactivity of Biotic and Abiotic Iron-Sulfur Motifs — 2011 NAI
- Structure, Reactivity, and Biosynthesis of Cataylic Iron-Sulfur Clusters — 2010 NAI
- Radical SAM Enzyme Functional Diversity and Evolution — 2010 NAI
- Structure, Function, and Biosynthesis of the Complex Iron-Sulfur Clusters at the Active Sites of Nitrogenases and Hydrogenases — 2009 NAI
- View all 10 projects
NAI Project Collaborators
- Project collaborators as reported by the latest NAI Annual Report.
-
Publications
-
Chandra, T., Silver, S. C., Zilinskas, E., Shepard, E. M., Broderick, W. E., & Broderick, J. B. (2009). Spore Photoproduct Lyase Catalyzes Specific Repair of the 5 R but Not the 5 S Spore Photoproduct. Journal of the American Chemical Society, 131(7), 2420–2421. doi:10.1021/ja807375c
See Project -
McGlynn, S. E., Boyd, E. S., Shepard, E. M., Lange, R. K., Gerlach, R., Broderick, J. B., & Peters, J. W. (2009). Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor. Journal of Bacteriology, 192(2), 595–598. doi:10.1128/jb.01125-09
See Project See Project See Project See Project See Project -
McGlynn, S. E., Boyd, E. S., Shepard, E. M., Lange, R. K., Gerlach, R., Broderick, J. B., & Peters, J. W. (2009). Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor. Journal of Bacteriology, 192(2), 595–598. doi:10.1128/jb.01125-09
See Project See Project -
McGlynn, S. E., Mulder, D. W., Shepard, E. M., Broderick, J. B., & Peters, J. W. (2009). Hydrogenase cluster biosynthesis: organometallic chemistry nature’s way. Dalton Trans., None(22), 4274. doi:10.1039/b821432h
See Project See Project See Project -
McGlynn, S. E., Shepard, E. M., Winslow, M. A., Naumov, A. V., Duschene, K. S., Posewitz, M. C., … Peters, J. W. (2008). HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis. FEBS Letters, 582(15), 2183–2187. doi:10.1016/j.febslet.2008.04.063
See Project -
Mulder, D. W., Shepard, E. M., Meuser, J. E., Joshi, N., King, P. W., Posewitz, M. C., … Peters, J. W. (2011). Insights into [FeFe]-Hydrogenase Structure, Mechanism, and Maturation. Structure, 19(8), 1038–1052. doi:10.1016/j.str.2011.06.008
See Project See Project -
Shepard, E. M., Boyd, E. S., Broderick, J. B., & Peters, J. W. (2011). Biosynthesis of complex iron–sulfur enzymes. Current Opinion in Chemical Biology, 15(2), 319–327. doi:10.1016/j.cbpa.2011.02.012
See Project See Project See Project See Project See Project See Project See Project -
Shepard, E. M., Duffus, B. R., George, S. J., McGlynn, S. E., Challand, M. R., Swanson, K. D., … Broderick, J. B. (2010). -Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide. Journal of the American Chemical Society, 132(27), 9247–9249. doi:10.1021/ja1012273
See Project See Project -
Shepard, E. M., McGlynn, S. E., Bueling, A. L., Grady-Smith, C. S., George, S. J., Winslow, M. A., … Broderick, J. B. (2010). Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proceedings of the National Academy of Sciences, 107(23), 10448–10453. doi:10.1073/pnas.1001937107
See Project - Shepard, E.M. & Broderick, J.B. (2009). S-Adenosylmethionine and iron-sulfur clusters in biological radical reactions: The radical SAM superfamily [Book Chapter]. Comprehensive Natural Products Chemistry II. Vol. In press. See Project
- Shepard, E.M. & Broderick, J.B. (2010). S-Adenosylmethionine and iron-sulfur clusters in biological radical reactions: The radical SAM superfamily. In: Mander, L.N. & Lui, H.W. (Eds.). Comprehensive Natural Products II: Chemistry and Biochemistry. Oxford, U.K: Elsevier Press. See Project See Project
- View all 11 publications
