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2012 Annual Science Report

Montana State University Reporting  |  SEP 2011 – AUG 2012

Radical SAM Chemistry and Biological Ligand Accelerated Catalysis

Project Summary

Iron sulfur (FeS) clusters are thought to be among the most ancient cofactors in living systems. The FeS enzyme thrust is focused on examining the structure, mechanism, and biosynthesis of the complex FeS enzymes nitrogenase and hydrogenase. Exciting recent results have identified important links between the biosynthesis of the H-cluster and FeMo-co and have outlined a new paradigm for the biosynthesis of complex FeS clusters. The observations made have provided direct links to the evolution of FeS biocatalysts from their mineral-based precursors.

4 Institutions
3 Teams
0 Publications
0 Field Sites
Field Sites