NAI
Shawn McGlynn
California Institute of Technology
Current Projects
- Radical SAM Chemistry and Biological Ligand Accelerated Catalysis — 2012 NAI
- Molecular Evolution: A Top Down Approach to Examine the Origin of Key Biochemical Processes — 2012 NAI
- Radical SAM Chemistry and Biological Ligand Accelerated Catalysis — 2011 NAI
- Molecular Evolution: A Top Down Approach to Examine the Origin of Key Biochemical Processes — 2011 NAI
- The ABRC Philosophy of Astrobiology and the Origin of Life Discussion Group — 2010 NAI
- Structure, Reactivity, and Biosynthesis of Cataylic Iron-Sulfur Clusters — 2010 NAI
- Origin of Life and Catalysis - Philosophical Considerations — 2009 NAI
- Structure, Function, and Biosynthesis of the Complex Iron-Sulfur Clusters at the Active Sites of Nitrogenases and Hydrogenases — 2009 NAI
- View all 8 projects
NAI Project Collaborators
- Project collaborators as reported by the latest NAI Annual Report.
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Publications
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Driesener, R. C., Challand, M. R., McGlynn, S. E., Shepard, E. M., Boyd, E. S., Broderick, J. B., … Roach, P. L. (2010). -Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine. Angewandte Chemie International Edition, 49(9), 1687–1690. doi:10.1002/anie.200907047
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Haydon, N., McGlynn, S. E., & Robus, O. (2010). Speculation on Quantum Mechanics and the Operation of Life Giving Catalysts. Orig Life Evol Biosph, 41(1), 35–50. doi:10.1007/s11084-010-9210-5
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McGlynn, S. E., Boyd, E. S., Shepard, E. M., Lange, R. K., Gerlach, R., Broderick, J. B., & Peters, J. W. (2009). Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor. Journal of Bacteriology, 192(2), 595–598. doi:10.1128/jb.01125-09
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McGlynn, S. E., Boyd, E. S., Shepard, E. M., Lange, R. K., Gerlach, R., Broderick, J. B., & Peters, J. W. (2009). Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor. Journal of Bacteriology, 192(2), 595–598. doi:10.1128/jb.01125-09
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McGlynn, S. E., Kanik, I., & Russell, M. J. (2012). Peptide and RNA contributions to iron-sulphur chemical gardens as life’s first inorganic compartments, catalysts, capacitors and condensers. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 370(1969), 3007–3022. doi:10.1098/rsta.2011.0211
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McGlynn, S. E., Mulder, D. W., Shepard, E. M., Broderick, J. B., & Peters, J. W. (2009). Hydrogenase cluster biosynthesis: organometallic chemistry nature’s way. Dalton Trans., None(22), 4274. doi:10.1039/b821432h
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McGlynn, S. E., Shepard, E. M., Winslow, M. A., Naumov, A. V., Duschene, K. S., Posewitz, M. C., … Peters, J. W. (2008). HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis. FEBS Letters, 582(15), 2183–2187. doi:10.1016/j.febslet.2008.04.063
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Mielke, R. E., Robinson, K. J., White, L. M., McGlynn, S. E., McEachern, K., Bhartia, R., … Russell, M. J. (2011). Iron-Sulfide-Bearing Chimneys as Potential Catalytic Energy Traps at Life’s Emergence. Astrobiology, 11(10), 933–950. doi:10.1089/ast.2011.0667
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Nitschke, W., McGlynn, S. E., Milner-White, E. J., & Russell, M. J. (2013). On the antiquity of metalloenzymes and their substrates in bioenergetics. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1827(8-9), 871–881. doi:10.1016/j.bbabio.2013.02.008
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Shepard, E. M., Duffus, B. R., George, S. J., McGlynn, S. E., Challand, M. R., Swanson, K. D., … Broderick, J. B. (2010). -Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide. Journal of the American Chemical Society, 132(27), 9247–9249. doi:10.1021/ja1012273
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Shepard, E. M., McGlynn, S. E., Bueling, A. L., Grady-Smith, C. S., George, S. J., Winslow, M. A., … Broderick, J. B. (2010). Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proceedings of the National Academy of Sciences, 107(23), 10448–10453. doi:10.1073/pnas.1001937107
See Project - Glass, J.B. & McGlynn, S.E. (2010). How do life and global geochemical cycles mutually affect each other? Astrobiology Primer, 2.0(4.2.3): In preparation. See Project
- Haydon, N., McGlynn, S.E. & Robus, O. (Submitted). Quantum mechanics and the emergence of life giving catalysts. Origin of Life and Evolution of Biospheres. See Project
- Orphan, V., Dekas, A., Green, A., House, C., Marlow, J., Steele, J., McGlynn, S. & Levin, L. (2011). Microbial partnerships and methane-oxidation in the deep sea. Goldschmidt Conference. Prague. See Project
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