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2009 Annual Science Report

University of Colorado, Boulder Reporting  |  JUL 2008 – AUG 2009

Executive Summary

1. Catalysis and the emergence of the genetic code (Shelley Copley, lead)

Summary of Recent Progress

Work on the project so far has focused upon the role of catalysis in the emergence of the genetic code (Copley, S. D., Smith, D. E., and Morowitz, H. G. “A Mechanism for the Association of Amino Acids with their Codons and the Origin of the Genetic Code”, Proceedings of the National Academy of Sciences, 2005, 102, 4442-4447) and in the emergence of the RNA World (Copley, S. D., Smith, E. and Morowitz, H. J. “The Origin of the RNA world”, Bioorganic Chemistry, 2007, 35, 430-443). Current work in collaboration with Smith and Morowitz is addressing the emergence of sparseness in metabolism. There are millions of possible small organic molecules, but the core metabolome of the chemolithoautotroph Aquifex aeolicus, which grows on CO2 and H2 and thus ... Continue reading.

Project Reports

  • There are no reports for this team in the 2009 annual report.