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2004 Annual Science Report

University of Washington Reporting  |  JUL 2003 – JUN 2004

Evolution of Biocomplexity From an Ancient Autotrophic Lineage

4 Institutions
3 Teams
0 Publications
0 Field Sites
Field Sites

Project Progress

The genome sequence of Methanococcus maripaludis is key to studying the evolution of the methanococcal lineage. The genome sequence has been completed and made publically available. A paper on the functional annotation has been submited. Another goal of the project is to use the genetic tools available for M. maripaludis, in concert with the genome sequence, to identify the minimal set of genes that is essential for viability. For this purpose and others, we have devised an efficient method for producing gene deletions in M. maripaludis. We have also carried out an analysis of lateral transfer of genes involved in utilization of alanine as a nitrogen source. A paper has been submitted that combines the latter two advances, focusing on the alanine utilization genes for mutagenesis and phylogeneitc analysis.

    John Leigh
    Project Investigator
    Maynard Olson

    Erik Hendrickson

    Jeremy Dodsworth
    Doctoral Student

    Objective 3.2
    Origins and evolution of functional biomolecules

    Objective 3.3
    Origins of energy transduction

    Objective 4.2
    Foundations of complex life

    Objective 5.2
    Co-evolution of microbial communities

    Objective 5.3
    Biochemical adaptation to extreme environments

    Objective 6.1
    Environmental changes and the cycling of elements by the biota, communities, and ecosystems

    Objective 6.2
    Adaptation and evolution of life beyond Earth