What is the best strategy for finding signs of life beyond the Solar System? Until recent years this was a purely philosophical question, but today we have the technical ability to search for signs of life on exoplanets around nearby stars, so the question is now a practical one. To start, we ask what kind of signs of life should we be looking for, and where should we be looking? Next we might ask about the methods we could use for such a search, and the kinds of evidence that we expect to obtain. Finally we can ask about the prospects for starting this search in the coming decade.